If you have to take prednisone to control the Lupus, how low a dosage will be effective? When taking Hydroxyquine & Methotrexate I had a flare of Lupus which caused me to have Shrinking Lung Syndrome and I lost half the capacity of my lungs. A combination of Prednisone and Immuran have settled everything down but I am having side effects from too much prednisone.