Cookies help us deliver our services. By using our services, you agree to our use of cookies. Learn more

Sertoli Cell-only Syndrome

What is Sertoli Cell-only Syndrome?

Sertoli cell-only syndrome is a rare disorder characterized by male sterility without sexual abnormality due to the absence of seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.

 

Sertoli cell-only syndrome is a rare disorder characterized by male sterility without sexual abnormality due to the absence of seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.
Acknowledgement of Sertoli Cell-only Syndrome has not been added yet.
Prevalence Information of Sertoli Cell-only Syndrome has not been added yet.
Synonyms for Sertoli Cell-only Syndrome has not been added yet.
Cause of Sertoli Cell-only Syndrome has not been added yet.
Symptoms for Sertoli Cell-only Syndrome has not been added yet.
Diagnosis of Sertoli Cell-only Syndrome has not been added yet.
Diagnostic tests of Sertoli Cell-only Syndrome has not been added yet
Treatments of Sertoli Cell-only Syndrome has not been added yet.
Prognosis of Sertoli Cell-only Syndrome has not been added yet.
Tips or Suggestions of Sertoli Cell-only Syndrome has not been added yet.
References of Sertoli Cell-only Syndrome has not been added yet.
Azoospermia and Sertoli-cell-only syndrome: hypoxia in the sperm production site due to impairment in venous drainage of male reproductive system. Created by sertoli
Last updated 30 Jan 2011, 04:56 PM

Posted by sertoli
30 Jan 2011, 04:56 PM

Gat Y, Gornish M, Perlow A, Chakraborty J, Levinger U, Ben-Shlomo I, Pasqualotto F. Andrology-Interventional Radiology Maynei Hayeshua Medical Center and Sub-Micron Research Department ofCondensed Matter Physics, Weizmann Institute of Science, Rehovot, Israel.Yigal.Gat@weizmann.ac.il Erratum in: • Andrologia. 2011 Feb;43(1):85. Abstract Sertoli-cell-only (SCO) syndrome, or germ cell aplasia, is diagnosed on testicular biopsy when germ cells are seen to be absent without histological impairment of Sertoli or Leydig cells. It is considered a situation of irreversible infertility. Recent studies have shown that varicocele, a bilateral disease, causes hypoxia in the testicular microcirculation. Destruction of one-way valves in the internal spermatic veins (ISV) elevates hydrostatic pressure in the testicular venules, exceeding the pressure in the arteriolar system. The positive pressure gradient between arterial and venous system is reversed, causing hypoxia in the sperm production site. Sperm production deteriorates gradually, progressing to azoospermia. Our prediction was that, if genetic problems are excluded, SCO may be the final stage of longstanding hypoxia which deteriorates sperm production in a progressive process over time. This would indicate that SCO is not always an independent disease entity, but may represent deterioration of the testicular parenchyma beyond azoospermia. Our prediction is confirmed by histology of the seminiferous tubules demonstrating that SCO is associated with extensive degenerative ischaemic changes and destruction of the normal architecture of the sperm production site. Adequate treatment of bilateral varicocele by microsurgery or by selective sclerotherapy of the ISV resumes, at least partially, the flow of oxygenated blood to the sperm production site and restored sperm production in 4 out of 10 patients. Based on our findings the following statements can be made: (i) SCO may be related in part of the cases to persistent, longstanding testicular parenchymal hypoxia; (ii) germ cells may still exist in other areas of the testicular parenchyma; and (iii) if genetic problems are excluded, adequate correction of the hypoxia may restore very limited sperm production in some patients.

Community External News Link
Title Date Link
Community Resources
Title Description Date Link

Clinical Trials


Cords registry

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. The registry is free for patients to enroll and researchers to access.

Enrolling is easy.

  1. Complete the screening form.
  2. Review the informed consent.
  3. Answer the permission and data sharing questions.

After these steps, the enrollment process is complete. All other questions are voluntary. However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. This is why we ask our participants to update their information annually or anytime changes to their information occur.

Researchers can contact CoRDS to determine if the registry contains participants with the rare disease they are researching. If the researcher determines there is a sufficient number of participants or data on the rare disease of interest within the registry, the researcher can apply for access. Upon approval from the CoRDS Scientific Advisory Board, CoRDS staff will reach out to participants on behalf of the researcher. It is then up to the participant to determine if they would like to join the study.

Visit sanfordresearch.org/CoRDS to enroll.

Community Leaders

 

Expert Questions

Ask a question

Community User List


Start a Community


Don't See Your Condition On Rareshare?

Start your own! With a worldwide network of 8,000 users, you won't be the only member of your community for long.

FAQ


Have questions about rareshare?

Visit our Frequently Asked Questions page to find the answers to some of the most commonly asked questions.


Communities

Our Communities

Join Rareshare to meet other people that have been touched by rare diseases. Learn, engage, and grow with our communities.

FIND YOUR COMMUNITY
Physicians

Our Resources

Our rare disease resources include e-books and podcasts

VIEW OUR EBOOKS

LISTEN TO OUR PODCASTS

VIEW OUR GUIDES

Leaders

Our Community Leaders

Community leaders are active users that have been touched by the rare disease that they are a part of. Not only are they there to help facilitate conversations and provide new information that is relevant for the group, but they are there for you and to let you know you have a support system on Rareshare.