Light Chain Deposition Disease is a rare disorder in which the monoclonal sFLC accumulates within cells in the kidneys and other organs.
|Edema||Edema is an abnormal accumulation of fluid beneath the skin or in one or more cavities of the body.|
|High blood pressure||High blood pressure that is often hard to control even with medication|
|Nephrotic syndrome||Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak large amounts of protein from the blood into the urine.|
It's a conjecture, but quite clearly the prednisone helped both maintaining kidney function or more accurately slowing down decline in kidney function and perhaps reducing light chain production. We saw quite clearly that after stopping the low dose prednisone, kidney function deteriorated more quickly. WAe also saw over time a decrease in light chain production. Re. the latter one can't know if it was the course of the disease for her or it was the result of the low dose prednisone. So the doc don't really know why it helped, we know it is very likely that it helped. The program at Boston University is another place to consult in addition to the Mayo. I hope this is helpful Best luck
Would like to see more activity here...but I guess the LCDD is pretty rare. My 76-yr-old hubby was dx with LCDD a little over a year ago after a high creatinine reading during a routine physical. The sad thing is that the reading had been elevated the previous year and the doc did not notice nor follow up. A year ago he tried velcade (major neuropathy) and then melphalan. His light chains dropped considerably but are rising again. The Onc's opinion was that his disease will not affect other organs...and since the kidneys are already non-functioning, they discontinued the chemo. As I mentioned a year ago, he's lost his kidney function and is on hemodialysis. We visited Mayo in Rochester and their review was "nothing can be done except dialysis". He is too old for stem cell. And a transplant is out of the question due to lcdd. He has one plus. He is able to still pass urine so it makes the kidney diet a bit easier. Barber, What was the reason (and the benefit) for the low dose prednisone? To help the kidneys continue to function??? Thanks for any response.
Sorry to hear Blondie. Very sinilar to what happened to my wife, as I wrote earlier dexa folllowed by low does prednisone was sufficient to help her for the last 10 years. The data indicates that Velcade should be very helpful. Best luck
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I have been recently diagnosed with smoldering myeloma and edema due to capillary leakage syndrome. The build up of fluid started last spring. I have been put on oral steroids which seems to take...
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