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Cushing's Syndrome

What is Cushing's Syndrome?

Cushing’s syndrome is a hormonal disorder. It occurs from extended exposure of the body to high levels of cortisol. Most commonly, this is caused by oral corticosteroid medicine. Cushing’s syndrome is also known as hypercortisolism.


Cushing’s syndrome is a hormonal disorder. It occurs from extended exposure of the body to high levels of cortisol. Most commonly, this is caused by oral corticosteroid medicine. Cushing’s syndrome is also known as hypercortisolism.
Acknowledgement of Cushing's Syndrome has not been added yet.
Synonyms for Cushing's Syndrome has not been added yet.
Cushing's Syndrome occurs when the body is exposed to high levels of cortisol for long periods of time. Many people develop Cushing's Syndrome because of glucocorticoid hormones such as prednisone for asthma, rheumatoid arthritis, lupus and other inflammatory diseases, or for immunosuppression after transplantation. Some people develop Cushing's Syndrome because of overproduction of cortisol by the body due to a pituitary adenoma which secretes excess ACTH, an adrenal adenoma which secretes excess cortisol, or an ectopic tumor which may secrete either ACTH or cortisol..
Most individuals affected experience moon face and central obesity. If they are children, they commonly experience slow growth rate. Skin infections, acne, slow healing, striae on the skin, and easy bruising also occur. Backache, bone pain and tenderness, fractures, and muscle weakness are also symptoms. In addition, a buffalo hump, or a mass of fat between the shoulders and above the collarbone, may form. Gender specific symptoms are excessive hair growth and irregular menstruation for women, and decreased libido and impotence for men. Other possible symptoms are mental changes, such as depression or anxiety, cognitive difficulties, fatigue, headache, hypertension, glucose intolerance, and more thirst and urination.
Name Description
Rapid weight gain Rapid weight gain
Excess sweating Excess sweating
Telangiectasia Telangiectasia is the dilation of capillaries.
Severe fatigue Severe fatigue
Striae Striae are irregular areas of skin that look like bands, stripes, or lines.
Buffalo hump Buffalo hump
High blood pressure High blood pressure that is often hard to control even with medication
High blood sugars and/or insulin resistance High blood sugars and/or insulin resistance
Insomnia Insomnia
Altered diurnal rhythm Altered diurnal rhythm
Secondary hypothyroidism Secondary hypothyroidism
Low hormones Low hormones such as FH, LSH, testosterone, growth hormone
Low vitamin D Low vitamin D
Low ferritin Low ferritin
Easy bruising Easy bruising
Muscle, bone, and joint pain Unexplained muscle, bone, and joint pain
Muscle weakness Muscle weakness
Hirsutism Hirsutism is increased facial hair/body hair
Loss of menstrual cycle and/or ovulation Loss of menstrual cycle and/or ovulation
Loss of libido Loss of libido
Galactorrhea Galactorrhea
Loss of hair on head Loss of hair on head
Difficulty when drawing blood Difficulty when drawing blood
A diagnosis is made with regards to the individual’s medical history, physical examination,, and laboratory tests. Extra tests are done, once Cushing’s syndrome has been diagnosed, to determine the cause of the excess cortisol production, be it inside the body or due to ingestion of cortisone.
Diagnostic tests of Cushing's Syndrome has not been added yet
If Cushing’s syndrome is being caused by corticosteroid use, a doctor will decrease corticosteroid use. In the event that this is not possible, other symptoms will be managed. If Cushing’s syndrome is being caused by a pituitary tumor, surgery, radiation, and cortisol replacement therapy may be required. In the case of an adrenal or other tumor, surgery may be required.
Tumor removal may lead to full recovery, or the condition may return. Cushing’s syndrome can be life-threatening if left untreated, and can result in diabetes, enlargement of the pituitary tumor, bone fractures, hypertension, kidney stones, and infections.
Name Description
C It is crucial for individuals with Cushing’s syndrome to not push themselves too hard physically, eat healthily, and monitor their mental health. Cognitive issues resulting from Cushing’s syndrome may improve through mental exercises such as Sudoku. Pain can be alleviated with low-impact exercise, hot baths, and massages.
References of Cushing's Syndrome has not been added yet.
Stretch marks Created by RichardB6
Last updated 12 Sep 2019, 02:00 PM

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12 Sep 2019, 02:00 PM

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Cushing's Syndrome? Created by vijhoni62
Last updated 6 May 2019, 09:51 AM

Posted by vijhoni62
6 May 2019, 09:51 AM

Cushing's Syndrome?

I would like to hear from people who have had or currently have Cushing's Syndrome. I want to know what your symptoms were and what treatment you had. I have read about it but I know disorders do not always effect all people in the same ways.

Welcome to the Cushing's corner! Created by fatnsassy
Last updated 28 Dec 2008, 02:22 AM

Posted by staticnrg
28 Dec 2008, 02:22 AM

Hey, ladies, I just joined and updated some of the info that was there. I'm not sure if they don't like what I said about the diagnostic tests or if they are waiting on approval....hmmmmmm...

Posted by suitechic1979
4 Aug 2008, 12:45 AM

Hi Gracie and everyone else. Thanks for joining me so I wasn't a loner in this group. :) I thought it would be nice to have a group here when I saw it and thought that we can help others learn about this illness. If anyone wants to add anything, I think that would be really cool.. to give more information about this disease. Welcome everyone!

Posted by fatnsassy
3 Aug 2008, 11:22 PM

I see there are three of us here now. Thanks for letting us know about this site Suitechic! It's another way for us to get the word out, and share our knowledge! Hopefully we will meet even more people through this site, and be able to help others as well. Hugs, Gracie

Welcome to RareShare Created by biotechguy
Last updated 19 Dec 2008, 10:31 PM

Posted by biotechguy
19 Dec 2008, 10:31 PM

Hi Everyone, My name is David Isserman and I am one of the co-creators of RareShare. I just wanted to quickly welcome you all to the Site. If you ever have any questions about RareShare or suggestions on improving the Site, please feel free to contact me at David

Community External News Link
Title Date Link
Recordati Rare Diseases Inc. Announces Availability of ISTURISA® (osilodrostat) in the United States 06/14/2020
Metopirone Safely Normalized, or Significantly Lowered, Urine Cortisol Levels in Phase 3/4 Trial 09/19/2020
Community Resources
Title Description Date Link
Cushings Help Organization

Cushings Help Organization provides information, support, RSS feeds, news, and education for people with Cushing's or other endocrine problems, their friends and families. Cushing's syndrome is a hormonal disorder.

Survive the Journey

A blog about the journey of a Cushing's Disease survivor. There you will find information on testing, diagnosis, and treatment. The latest research is outlined, also.



The author talks about the personal side of her journey at times, and she relates the medical aspects in language anyone can understand.


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CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. The registry is free for patients to enroll and researchers to access.

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After these steps, the enrollment process is complete. All other questions are voluntary. However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. This is why we ask our participants to update their information annually or anytime changes to their information occur.

Researchers can contact CoRDS to determine if the registry contains participants with the rare disease they are researching. If the researcher determines there is a sufficient number of participants or data on the rare disease of interest within the registry, the researcher can apply for access. Upon approval from the CoRDS Scientific Advisory Board, CoRDS staff will reach out to participants on behalf of the researcher. It is then up to the participant to determine if they would like to join the study.

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2002 - Diagnosed with a bronchial neuroendocrine tumour (4cm). Surgically removed; no further treatment required.

2011 - Diagnosed with Ectopic Cushing's Syndrome.  No ACTH/steroid...

Master's degree in human Nutrition


Master's degree in education


PhD candidate in health science
I have a 18 year old son who has had two transphenoidal surgeries. One in October 2010 and one in October 2011.
im a mother of two my daughter is nine and son is going to be three.
am an advocate, researcher, and patient with Cushing's Disease, a rare, often misunderstood illness. In sharing my journey, I hope to make others more aware of the illness and more enabled to...
Hi There,



Now post op (adrenalectomy). Not feeling much better yet. Any advice? Anything I can do in the meantime? I'm tired and have a very large stomach that is horribly...
It started with Stevens Johnsons Syndrome- a disease I was afflicted w/ induced by a drug called Lamictal, a mood stabalizer given to me in the hospital to fight my depression due to losing my son....
I'm a post-op Cushing's patient who is doing very well and wants to help spread the word about this supposedly rare disease.
I have Cushing's disease. For me, it is caused from a pituitary tumor. I will soon be having surgery to remove my tumor, and hopefully have a cure.

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Discussion Forum

Stretch marks

Created by RichardB6 | Last updated 12 Sep 2019, 02:00 PM

Cushing's Syndrome?

Created by vijhoni62 | Last updated 6 May 2019, 09:51 AM

Welcome to the Cushing's corner!

Created by fatnsassy | Last updated 28 Dec 2008, 02:22 AM

Welcome to RareShare

Created by biotechguy | Last updated 19 Dec 2008, 10:31 PM


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