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Adrenocortical Carcinoma

What is Adrenocortical Carcinoma?

Adrenocortical carcinoma is a rare form of cancer originating in the cortex of the adrenal gland.

 

Adrenocortical carcinoma is a rare form of cancer originating in the cortex of the adrenal gland.
Acknowledgement of Adrenocortical Carcinoma has not been added yet.
1.0http://www.orpha.net
Synonyms for Adrenocortical Carcinoma has not been added yet.
One form of ACC is caused by mutation in the TP53 gene, which maps to chromosome 17p13. At least 50% of adrenocortical carcinomas are inherited. Both autosomal dominant and autosomal recessive inheritances have been reported.
Virilization is the most common symptom of ACC, most obvious in women, producing excess facial and body hair, acne, enlargement of the clitoris, deepening of the voice and cessation of menstruation. In men, estrogen excess is noted, leading to breast enlargement, decreased libido and impotence. Cushing’s Syndrome occurs in approximately one third of cases, signs of which include moon-like faces, centripetal fat distribution and plethora.
Hormonal syndromes should be confirmed with laboratory testing. Radiological studies of the abdomen, such as CT scans and magnetic resonance imaging are useful for identifying the site of the tumor, differentiating it from other diseases, and determining the extent of invasion of the tumor into surrounding tissues.
Diagnostic tests of Adrenocortical Carcinoma has not been added yet
Complete, radical surgical resection is the treatment of choice and may be curative, especially for small tumors. Radiation therapy and radiofrequency ablation may be used for palliation in patients. In patients with incomplete resection or metastatic spread, treatment options include chemotherapy and/or mitotane.
The overall 5-year survival rate for ACC is 36%.
Tips or Suggestions of Adrenocortical Carcinoma has not been added yet.
References of Adrenocortical Carcinoma has not been added yet.
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CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. The registry is free for patients to enroll and researchers to access.

Enrolling is easy.

  1. Complete the screening form.
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After these steps, the enrollment process is complete. All other questions are voluntary. However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. This is why we ask our participants to update their information annually or anytime changes to their information occur.

Researchers can contact CoRDS to determine if the registry contains participants with the rare disease they are researching. If the researcher determines there is a sufficient number of participants or data on the rare disease of interest within the registry, the researcher can apply for access. Upon approval from the CoRDS Scientific Advisory Board, CoRDS staff will reach out to participants on behalf of the researcher. It is then up to the participant to determine if they would like to join the study.

Visit sanfordresearch.org/CoRDS to enroll.

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