15q 26.2 Deletion
What is 15q 26.2 Deletion ?
15q26 deletion is a genetic condition in which a small piece of DNA (genetic material) is missing from one of the 46 chromosomes, specifically from the q (long arm) of chromosome 15 (see RareShare Guide on Genetic Inheritance). Depending on the particular region missing, it can be referred as 15q26.1, 15q26.2, or 15q26.3 deletion. Deletions of any of these regions can, to varying extents, affect childhood growth and development.
Synonyms
- Distal 15q deletion syndrome
- Monosomy 15q26
- Telomeric 15q deletion syndrome
15q26 deletion is a genetic condition in which a small piece of DNA (genetic material) is missing from one of the 46 chromosomes, specifically from the q (long arm) of chromosome 15 (see RareShare Guide on Genetic Inheritance). Depending on the particular region missing, it can be referred as 15q26.1, 15q26.2, or 15q26.3 deletion. Deletions of any of these regions can, to varying extents, affect childhood growth and development.
Rareshare would like to acknowledge Dr. Michael Joseph O’Grady, Department of Paediatrics, Midland Regional Hospital, Co. Westmeath, Ireland; and Professor Anne Slavotinek, Professor of Clinical Pediatrics, University of California, USA for reviewing this content. We would also like to thank Usman Kamran for compiling this information.
15q26 deletions are extremely rare, with a prevalence of less than 1 in 1,000,000.
| Name | Abbreviation |
|---|---|
| Distal 15q deletion syndrome | Distal 15q deletion |
| Monosomy 15q26 | Monosomy 15q26 |
| Telomeric 15q deletion syndrome | Telomeric 15q deletion |
Most 15q26 mutations are regarded as de novo mutations, meaning that they arise spontaneously. They are generally caused by a mistake in the formation of the sperm or egg cells, or in the early days following fertilization. De novo mutations are not inherited and there is no family history of the disorder. Currently, there are no environmental factors known to cause these changes.
The symptoms and how severe the disorder will be can vary among affected children. Children in general display symptoms involving, to varying extents, childhood developmental delays. These may involve delays in communication, the development of language, and difficulty learning. Delays in developing motor skills including sitting up or crawling also occur.
In many cases, infants require additional support when feeding. They are observed to have bendy joints, and their facial features are sometimes distinctive and different from those of the rest of the family. In some cases, an observable defect in the diaphragm, known as a diaphragmatic hernia, has been observed. The diaphragm is the muscle that separates the chest cavity from the abdominal cavity. A hernia means that there is a hole in the diaphragm, which can allow organs from the abdominal cavity to push into the chest cavity. Heart problems have also been found in babies, involving an unusual formation, narrowing, or blockages of valves
regulating cardiac blood flow.
Babies with 15q26 deletions have been observed to be very small at birth and have continued growth delays. Babies with 15q26.1 and 15q26.2 deletions are more prone to have seizures.
DNA sequence analysis methods are currently the primary means to detect this deletion. If the deletion is large enough it can be also be detected by looking at a DNA karyotyping preparation under the microscope.
See above.
There are currently no known cures for this disease. Some studies have reported a limited benefit with growth hormone therapy for some children with 15q26.3 deletions.
Presently, symptoms of the condition are treated as they present themselves.
There have been varied outcomes for patients with 15q26 deletions. Of the 24 reported cases studied by Unique, three were unable to overcome childhood heart and lung complications. 14 are reported to be healthy and rarely ill, whilst the remainder suffer from occasional health concerns.
https://www.omim.org/clinicalSynopsis/612626
https://www.rarechromo.org/information/Chromosome%2015/15q%20deletions%20FTNW.pdf
https://www.rarechromo.org/information/Chromosome%2015/15q26%20deletions%20FTNW.pdf
https://www.researchgate.net/publication/275668472_Recombinant_Human_Growth_Hormone_Therapy_in_Children_with_Chromosome_15q26_Deletion
http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=1737&Disease_Disease_Search_diseaseGroup=15q26&Disease_Disease_Search_diseaseType=Pat&Disease%28s%29/group%20of%20diseases=Distal-monosomy-15q&title=Distal-monosomy-15q&search=Disease_Search
Last updated 8 Jun 2026, 03:38 PM
8 Jun 2026, 03:38 PM
Hi Everyone-
Catching up on this forum! I'm a balanced translocation carrier 15/19, 26.2 and 13.3 and my daughter Natalie has a unbalanced translocation. She is missing the distal end of her 15th chromosome at 26.2 and in it's place she has the small piece of the 19th chromosome at 13.3 (they call it a micro duplication and deletion). She was exremely small for her age and started on growth hormone and was on it for maybe 6 yrs? I can't quite remember but it helped so much. The only thing to really monitor and unfortunately for her it just happened so fast is she developed a serious scoliolis while on the growth hormone and that's been a problem. She is 5 foot 3 inches which is a generally functional height. She is 31 yrs old and is functioning well and able to read, write, do math, manage her needs for the most part but is also not a typical 31 yr old; she does have a mild intellectual disability and needs support with some things; she doesn't drive. It's great to read these posts and feel like there are some others out there to relate to; we are a rare group for sure! Hope you all are doing okay and would love to get an update since these posts are quite older and now we are in 2026! Thank you all.
Lisa Graham
Cincinnati OH
22 Sep 2021, 09:34 PM
My daughter has 15q26.2-26.3 deletion including the IGF1R gene. She has minimal side effects, mostly just short stature. She's the only one in New Zealand diagnosed with this at the moment, so it's a bit tough with no medical staff having much of an idea about the deletion. I have to have all the information myself.
Has everyone seen the UNIQUE brochure on https://rarechromo.org/disorder-guides/ ? Click on English, scroll down to Chromosome 15, and next to 15Q26 click View. Lots of info, this is what my paediatrician printed out for us on diagnosis.
Also, check out the Magic Foundation at https://www.magicfoundation.org/ , if you email them they can do a screening for you and the report gives helpful info to show your medical staff. They're interested in getting anonymous data from other IGF1R deletion people, which should help us all.
28 Oct 2020, 12:36 AM
I'm a 20-year-old who is currently a sophomore majoring in biology. I have a huge passion for genetics because of my diagnosis of 15q26.2 deletion. I was told that I'm the only case (so far) with very minimal side effects from this disorder. The only effects I have are short stature and a compromised immune system. I was diagnosed sometime in 2009-2012
Last updated 8 Jun 2026, 03:28 PM
8 Jun 2026, 03:28 PM
Hi there- Catching up on this forum. I am a balanced translocation carrier (15 (26.2) and 19 (13.3), and my daughter has an unbalanced translocation, and is missing the distal end of her 15th chromosome at 26.2 and in it's place has a small piece of chromosome 19 so she is monosomonic for that segment of 15 and trisomic for that segment of 19. She is 31 yrs old and is doing okay but not a typical adult her age. Where are you located? I live in Cincinnati OH. Hope your daughter is doing ok and happy to chat with you. I know it can be a difficult journey when you aren't sure about how things will turn out.
Sincerely,
Lisa Graham
mom to Natalie
12 Mar 2025, 05:30 AM
Hi everyone, I see that the last discussion was posted in 2021. I am not sure if anyone is active still but would love to connect. My daughter has been dx with 15q26.2 deletion. She just turned one not too long ago. Please feel free to comment or send me a message. Thank you in advance.
Last updated 29 May 2026, 10:25 AM
29 May 2026, 10:25 AM
Looking to enhance focus, improve cognitive performance, and manage attention deficit hyperactivity disorder (ADHD) symptoms? Look no further than the latest stock of Adderall available online! With just a few clicks, you can conveniently buy Adderall online and experience the unparalleled benefits it offers. Harnessing the power of its active ingredients - amphetamine and dextroamphetamine - this medication stimulates the central nervous system, helping individuals maintain better concentration levels while curbing impulsivity. Whether you're a student preparing for exams or an adult seeking enhanced productivity at work, buying Adderall online opens up a world of possibilities for achieving your goals efficiently. Rest assured that our quality-controlled inventory guarantees authentic products that are safe and effective. Say goodbye to distractions and hello to laser-like focus with Buy Adderall Online!
Unlock a world of convenience with our hassle-free solution – buy Adderall online, without the need for a visit to the doctor's office. Embrace efficiency and reclaim your time with a seamless online experience.
Experience the freedom to manage your well-being on your terms. Say goodbye to lengthy appointments and embrace the simplicity of obtaining Buy Adderall from the comfort of your own space. No more waiting rooms, no more delays – just a straightforward process tailored to your needs.
Buy Adderal
Buy Adderall Online 30 mg
Buy Adderall XR Online 30 mg
Last updated 9 Jan 2018, 07:10 AM
9 Jan 2018, 07:10 AM
My daughter who is now 4 was diagnosed just after birth, have never searched before for other families. Anyone out there have a child with same disorder?
Clinical Trials
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. The registry is free for patients to enroll and researchers to access.
Enrolling is easy.
- Complete the screening form.
- Review the informed consent.
- Answer the permission and data sharing questions.
After these steps, the enrollment process is complete. All other questions are voluntary. However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. This is why we ask our participants to update their information annually or anytime changes to their information occur.
Researchers can contact CoRDS to determine if the registry contains participants with the rare disease they are researching. If the researcher determines there is a sufficient number of participants or data on the rare disease of interest within the registry, the researcher can apply for access. Upon approval from the CoRDS Scientific Advisory Board, CoRDS staff will reach out to participants on behalf of the researcher. It is then up to the participant to determine if they would like to join the study.
Visit sanfordresearch.org/CoRDS to enroll.
Community Leaders
Expert Questions
Ask a question
Community User List
I'm a 20-year-old Korean American. Currently, a sophomore in college majoring in biology (possibly double majoring with psychology). I'm heavily passionate about genetics because of my...
Balanced translocation 15 (26.2), 19 (13.3); one unbalanced daughter, monosomic for segment of 15, trisomic for segment of 19.
I'm a father and grandfather and a widow of my loving wife of 22 years.
I'm seeking possible ways in which I could see a...
12 months ago. Now on methotrexate and prednisolone with gradual reduction. Feeling very well.
Im searching Australia to find others with this in order to gain knowledge to help my son.
I am a french woman who suffers capillary leak syndrome.
Doctors diagnosed two weeks ago .
I would like to discuss with you because there is no forum about this ill in...
Languages disorder
Pica
Simple phobias
Seperation anniepy
Development delay
Chromosome 22q11.2t
...
...
with fears to face this kind...
I have the pleaser to write about my casI`ll try to explain about may case .
All start at 17/02/2008 I had a cove and I went to the emergency they give me anti biotic it was...
Start a Community
Don't See Your Condition On Rareshare?
Start your own! With a worldwide network of 8,000 users, you won't be the only member of your community for long.
FAQ
Have questions about rareshare?
Visit our Frequently Asked Questions page to find the answers to some of the most commonly asked questions.
Discussion Forum
New to Group
Created by sortiz | Last updated 8 Jun 2026, 03:28 PM
TELEGRAM: DRMIKE100 TO BUY ADDERALL IN USA WITHOUT SCRIPT
Created by human health | Last updated 29 May 2026, 10:25 AM
15q26.1 deletion
Created by Gilly | Last updated 9 Jan 2018, 07:10 AM
Our Communities
Join Rareshare to meet other people that have been touched by rare diseases. Learn, engage, and grow with our communities.
FIND YOUR COMMUNITY
Our Resources
Our rare disease resources include e-books and podcasts
Our Community Leaders
Community leaders are active users that have been touched by the rare disease that they are a part of. Not only are they there to help facilitate conversations and provide new information that is relevant for the group, but they are there for you and to let you know you have a support system on Rareshare.