Hello everybody Has anybody experienced that their ddavp is not working well. After 5 or 6hrs, I have to take another dose again. Sometimes it even worse, it's only last for 4-5hrs. A dose is suppose to last about 8 hrs. I'm taking spray ddavp. Can stress wear off the ddavp? Thank you.

Hi Rose-- What is ddavp? Never heard of it.

Hi Nancy Ddavp is hormone made (synthetic) to replace natural hormone ADH. Also known as minirin. It is to replace vasopressin, the hormone to control urine. My body cannot contain water, no matter how much I drink. If not treated, we will have severe dehydration problem because all of the water will be passed out through urine. Extreme thirst and extreme urination are the symptoms. This disease is called Diabetes Insipidus. It caused either by pituitary failure or kidney failure ie the kidney fail to response to ADH hormone produced by the pituitary. I assume your pit still produce ADH. Is it?

Rose, Unfortunately, I have the same problem. I had a pituitary apoplexy in 2009 with secondary panhypopituitarism & diabetes Insipidus. Long story short...I was started on Desmopressin nasal spra, one spray each nostril before bed. This worked for a while and my body adapted and required more and more. Now, I am taking both the nasal spray ( 2 sprays each nostril in the morning and before bed) and oral Desmopressin morning and night. My Endocrinologist reports I have doubled the recommended dose and that for some individuals the body just metabolizes this medication more rapidly than others making it less effective. Unfortunately, since this is a vasoconstrictor...the medication is also dangerous...too much can constrict the blood vessels in the the major organs such as the heart and kidneys resulting in a greater of two evils: heart or kidney failure versus dehydration from the diabetes Insipidus.

Hi Jedwards I’m glad you responded. At least I know I’m not alone. I’m a bit scared with my condition now. I now write in my journal when I start with new bottle. I didn’t know about it being a vasoconstrictor. My endo never mention about it, even though I’ve been seeing them for many years. Wonder whether they know about this. On my last visit to endo recently, I asked her about this non-functioning thing. She said it’s okay to take extra doses if I need it. If symptoms worsening while I’m taking the extra doses, she asked me to call them. Thank you again.