My husband and I have been talking a lot lately, and as much as we've hated to come to the decision, we've decided since I passed the deletion to Frankie instead of hi getting it De Novo, not to have try and have any more children. Frankie was conceived on Chlomid so it's unlikely, but if it happens it happens. But then I found this group and we were wondering: 1) Did any of you get tested to see if you had a 4q deletion as well? 2) If you had any children after the child who has the deletion, do they have it as well? 3) Does anyone have research on the odds? From what little the 2 geneticists have told us, there is a 50/50 chance of our next child having it, but the odds are slightly higher in favor because Frankie is our first born and has it.

My husband and i did NOT get tested since Henry, my "4q-tee", my third, is our last (got a tubal). The geneticists want to test Sam and Thom because even though they do not exhibit any signs of any abnormalities, there is still a chance they have a break in the chromosome somewhere which might pass it down to THEIR children. I don't completely understand that, but that is how i've understood it. We have not had them tested yet because they are 4 and 20 mos old. And then of course, if we are to anticipate the delays and disabilities Henry is supposedly slated to have (based on research), i cannot imagine HIM procreating (is that wrong of me to say?), but surely he would have a chance of passing it down, but not 100%.

From what I understand if it's trans-located instead of terminal, it's 25% of the 50% he will pass it on to his children where if it's terminal like Frankie, it'll be the full 50%. Unless his wife has it as well then it's 75% - 100% they will pass it on. The risk for the 2 non 4qtee's to pass it on is slightly greater because there is a family history off it, but only 25% instead off 0%. The weird thing is, Genetics was the one thing in Biology I excelled at, but even this confuses me!