Hi,

I want to inform you that I recently had an attack,

The attack was most likely triggered by an allergic reaction to an antibiotic (piperacillin/tazobactam).

I had taken this antibiotic several times in the past without any problems. And this time, I had been taking it for over two weeks.

The attack started one week before the regular IVIG administration.

The doctors quickly got the attack under control by administering IVIG and human albumin. I was in the hospital for 9 days, but only in a normal ward.

This is the first attack (I've had three in the past) where I'm pretty sure I know the trigger. 

I wanted to share this trigger here.

Yours

Andreas

Andreas,

I'm sorry to learn that you had an episode of SCLS, but I'm glad to hear that you received state-of-the-art care, namely, the early administration of IVIG and albumin, hopefully without the addition of massive amounts of other fluids which only complicate matters.

As concerns the hypothesis that the episode was triggered by an allergic reaction to the antibiotics (piperacillin plus tazobactam), given that you had taken this antibiotic combination before without experiencing any such "allergic reaction" and episode of SCLS, you and your doctors should consider the more likely hypothesis that the episode was triggered by the infection that those antibiotics were intended to fight.

To be sure, the most frequent trigger of episodes of SCLS are viral, as opposed to bacterial, infections -- the kind you probably had. I myself had a serious bacterial infection two years ago and I was afraid that it would trigger an episode of SCLS, but fortunately it did not.  

Hi Arturo,

 

thanks for your answer.

It will probably never be possible to say with certainty what triggered the attack.

The reason for the Pip-Taz was a bacterial infection with Pseudomonas aeruginosa in my left lower leg, where I had a fasciotomy 12 years ago due to the first attack.

I had been having problems since December 2024. The infection required a total of three surgeries (due to relapses) and I was given Pip-Taz three times. The first two times, there were no problems with the SCLS. The third time, the problems started after three weeks: a reaction to Pip-Taz and then an attack.

It may well be that the attack was not triggered by the reaction to Pip-Taz but by something else. Even another infection (according to my blood values). I was pretty exhausted and tired during that time.

 

Andreas

Hi Andreas,

Thanks for sharing your experience, that sounds incredibly tough with the repeated surgeries and infection. For me, I’ve noticed that my leakage is triggered by amoxicillin and penicillin-derived antibiotics, and also by certain foods like blue cheese, gorgonzola, and brie.

I hope you're feeling better 

Valeria

Hi again,

Has anyone here had to go through treatment for H. pylori? I’ve been prescribed Pylera, which contains bismuth subcitrate potassium, metronidazole, and tetracycline. I was told it’s safe since it’s penicillin-free, but I’d feel much more reassured if I heard from someone else here who has experience with it.

Thx in advance!

Val.