I am also interested in the role of cytokines in SCLS.
I suffer from a probable milder but chronic version of SCLS. I have an episode approximately twice a week, although some things influence it like weather where it is worse in rising temperature and air pressue. I have elevated cytokines and my intergrative doctor feel that this is the route of my issue. He says that mast cells are releasing excessive cytokines along with other mediators.
For example, see especially Interlukins 8, 10 and 13
Interlukin 1 Range (0.0-2.8) result 5.9
Interlukin 6 (0.0-11). 23.6
Interlukin 7 (0.0-17). 20.7
Interlukin 8 (0.0-28). 223.2
Interlukin 17. < 13. 25.6
TNFa (0.0-13) 16.7
TNFb. (0.0-156). 106.5
Interlukin 4 (0.0-190). 71.3
Interlukin 5 (0.0-13). 55.5
Interlukin 10 (0.0-11) 199.1
Interlukin 13 (0.0-6) 301.1
INFg (0.0-28) 47.8
Is this a mild cytokine storm ? I am not really sure, but would love to hear the thoughts of anyone else that also ponders these isues. I also worry what Covid-19 might do to me when cytokines are elevated on a good day, although I do feel blessed to live in Sydney where things are currently very mild.
I hope you all stay well in these difficult times.