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Any Impact on IVIG availability due to Coronaviris

WazzaACT Message
5 Mar 2020, 12:29 PM

Hi All

I certainly do not want to cause any alarm but I am interested to know if anyone is aware of any impact on IVIG availability because of the coronavirus. I am not but I would like to know if anyone else has any information.

aporzeca Message
5 Mar 2020, 05:24 PM

I did a search on the Internet and didn't find anything about a shortage of IVIG. 

On the supply side, I saw that the Plasma Protein Therapeutics Association (PPTA), an international organization with offices in Asia, Europe and the USA, had issued a statement (on February 17, 2020, as updated) stating that the coronavirus is not a concern for the safety of plasma protein therapies, including IVIG, manufactured by PPTA member companies, in large measure because "donor screening procedures are in place to prevent individuals from donating plasma who show typical disease symptoms (raised temperature/ fever, cough, difficulty breathing) of a coronavirus infection, including COVID-19.  The SARS-CoV-2 is a large sized virus (approximately 120 nm in diameter). The relatively large size and lipid envelope makes it highly susceptible to steps with virus inactivation and removal capacity used during the manufacturing processes, such as solvent-detergent (S/D), low pH incubation, caprylate-, pasteurization- or dry-heat treatments, nanofiltration or fractionation processes and others. The effectiveness of these processes has been demonstrated on other lipid-enveloped model viruses which are quite similar to 2019-nCoV, e.g. human coronavirus 229E and OC43, SARS-CoV, and porcine coronavirus TGEV" see https://www.pptaglobal.org/media-and-information/ppta-statements/1055-2019-novel-coronavirus-2019-ncov-and-plasma-protein-therapies

On the demand side, however, I see that there is a recent (February 24) WHO report on the virus and it makes mention, on page 37, that in the clinical management of severe and critically ill coronavirus patients, the effectiveness of additional investigational treatment options, including IVIG, is an option that physicians may want to try, see https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf  Obviously, this is a potential concern for the rest of us users.

Rita Wood Message
6 Mar 2020, 04:23 PM

My concern is the impact on production . The clinic I receive treatment at had a shortage before covid. They also had a shortage of regular iv fluid due to  storms in the production area. I hopes we don’t face problems. I kind of feel there are so few of us with Scls that very few people know about our group or for that matter care.

 

 

Rita Wood Message
6 Mar 2020, 04:26 PM