From everything I have read, I learned that prednisone should not be tapered too quickly. I am not sure what "too quickly" means. I was diagnosed with Antisynthetase syndrome at the end of May (including interstitial lung disease) and have been on oxygen since May 11. I am slowly staring to need less oxygen and my Dr. is starting to taper the prednisone from 160 mgs to 120 mgs to 80 mgs to 40 mgs (two week intervals). This seems like a relatively quick taper and I am concerned because I do not wish to have a flare up or for my lungs to hit a plateau in the recovery. What do you think?