Are there any who have had IVIG intolerance, and have been considered for Bevacizumab as an alternative?

Hello Jcarson, Please read "discussion" at the end of the article Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome),May 3, 2012; Blood: 119 (18) (http://www.bloodjournal.org/content/119/18/4321.short?sso-checked=true). Best regards. Claude Pfefferlé

Hello Claude, Yes, the paper does suggest that there is little efficacy in vitro; but I question whether this discussion should be focussed in light of an extra 4 years of clinical experience with the drug in oncology, and ocular indications. Of course IVIG would remain first line. This is only for those where IVIG. couldn't be used. Some time in the future, we would need to compare nesvacumab with bevacizumab clinically, for a second line. Cheers John