My pre-meds: Benadryl, Tylenol, Atavan, and Solumedrol. Main issue seems to be the Solumedrol makes me a little on edge and flushed; not sure on how the Benadryl affects me. I would never go without it(the Solumedrol) though as the headaches were unbearable. I have pretty good luck with the Benadryl it seems, as I take it the next few days to help with sleep that is a little tougher due to the Solumedrol. My body seems to have adjusted pretty well to the whole process. Sorry I am not more help.