I did a quick review of the medical and scientific literature on IVIG, which is vast because IVIG has been used as a therapy for a variety of illnesses for over six (6) decades, such that literally thousands of articles have been written about IVIG and its uses.
Immunoglobulin preparations were first used during the 1950s as a replacement therapy for primary immunodeficiency disorders. Initially, these were administered by intramuscular injection, but in the early 1980s, highly purified suspensions of immunoglobulin for intravenous use became available, as manufactured by different companies all over the world.
IVIG is a biological, natural product distilled from human blood donations, and potentially important product-manufacturing and single-batch differences have been known to exist -- as is the case with all blood products.
It is perhaps for this reason that adverse effects appear to vary considerably among different IVIG preparations available in the market, and also among the patients who receive it, because everyone reacts to IVIG in different ways -- because we are different one from the next.
The good thing is that symptoms of adverse reactions tend to occur within 1 to 6 hours from the start of an infusion, and they are affected by fast infusion rates, and thus managed largely by reducing the rate of infusion. Other adverse reactions can be prevented or managed by medications such as antihistamines and corticosteroids.
My conclusion from what I read is: *There are no known adverse, long-term side effects of an IVIG therapy.* And considering that IVIG has been used as a medication for over sixty years on all kinds of critically ill patients, if there were any such long-term side effects, we would know them by now.
Feel free to get yourself acquainted with the literature by going to the best website, _http://www.ncbi.nlm.nih.gov/pmc/_