I'm one of the oldest documented cases of Homocystinuria (HCU) --I'm 45 years old. I have have CBS enzyme deficiency but have no manifestation of the disorder (only detected by blood tests). My older brother (3 yrs older) has the classical symptoms but fortunate for both of us we were also the first documented cases in the 1970s to respond positively to B6. Recently I also have been diagnosed with Familial Mediterranean Fever