There have been several postings about how one person has much worse symptoms than others of the same age or older. Genetics is still an imperfect science; just by knowing we have the gene we can't predict how bad symptoms will be or when they occur. There was a PBS show several years ago called 'The Ghost in the Gene"; it indicated that we still don't know why or when a gene is "turned on.' Several years ago my sister, 4 1/2 years younger than I, but with much worse symptoms, participated in a study at Kennedy-Krieger institute. Results: evidently my "bad gene" didn't turn on as early as hers. We were told whether a gene turns on appears (at this point) to be random.