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Acrodermatitis Enteropathica

What is Acrodermatitis Enteropathica?

Acrodermatitis enteropathica is a metabolic disorder due to zinc insufficiency. Zinc is a trace element that is required for the correct function of many proteins in the body. When zinc is missing the malfunction of these proteins causes the inflammation of the skin around the body openings (especially the mouth and anus) and around the nails and toes. The lack of zinc can also cause diarrhea and hair loss.

If people do not eat enough zinc in the diet, they can also present with the symptoms of acrodermatitis enteropathica. In this case it is what is called an acquired form of the disease and can be treated with zinc supplements. The primary or genetic form of the disease is caused by mutations in the SLC39A4 gene, which provides the instruction for the production of the protein ZIP4. ZIP4 is a transporter present in the small intestine that uptakes the zinc present in the food that we eat.

Acrodermatitis enteropathica is also known as Brandt syndrome and Danbolt-Closs syndrome.

 

Acrodermatitis enteropathica is a metabolic disorder due to zinc insufficiency. Zinc is a trace element that is required for the correct function of many proteins in the body. When zinc is missing the malfunction of these proteins causes the inflammation of the skin around the body openings (especially the mouth and anus) and around the nails and toes. The lack of zinc can also cause diarrhea and hair loss.

If people do not eat enough zinc in the diet, they can also present with the symptoms of acrodermatitis enteropathica. In this case it is what is called an acquired form of the disease and can be treated with zinc supplements. The primary or genetic form of the disease is caused by mutations in the SLC39A4 gene, which provides the instruction for the production of the protein ZIP4. ZIP4 is a transporter present in the small intestine that uptakes the zinc present in the food that we eat.

Acrodermatitis enteropathica is also known as Brandt syndrome and Danbolt-Closs syndrome.

Acknowledgement of Acrodermatitis Enteropathica has not been added yet.

0.2http://www.orpha.net

Synonyms for Acrodermatitis Enteropathica has not been added yet.
Cause of Acrodermatitis Enteropathica has not been added yet.
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Diagnosis of Acrodermatitis Enteropathica has not been added yet.
Diagnostic tests of Acrodermatitis Enteropathica has not been added yet
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Visit sanfordresearch.org/CoRDS to enroll.

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